• Blocks VEGF, FGF, and angiopoietin — inhibits tumor blood vessel formation
• Epigenetic action: inhibits DNMT and HDAC, reactivating silenced tumor suppressor genes
• Suppresses NF-κB, the master inflammation switch exploited by cancer cells
• Induces apoptosis via mitochondrial and death-receptor pathways
• Inhibits mTOR — a target shared by several modern targeted therapies

Take with a fat-containing meal. Always choose a piperine or liposomal formulation. Do not exceed 2 g/day without medical supervision — antiplatelet effect at high doses.

• Inhibits VEGF and HER2/EGFR receptors
• Induces apoptosis and arrests cancer cell cycle at G1 phase
• Stimulates autophagy — synergistic with fasting protocols
• Inhibits TERT (telomerase) — the enzyme allowing cancer cells to divide indefinitely
• Epigenetic: demethylates silenced tumor suppressor genes

• Ceremonial grade matcha: 1–2 tsp in 70°C water, 1–2× daily
• Loose leaf green tea: 2 g per 200 ml at 75–80°C, 2 min steep, 3–4 cups/day
• Add lemon juice — increases EGCG stability and absorption in the gut
• Do NOT add milk — casein binds EGCG and blocks absorption

• Beta-glucans (polysaccharides): activate macrophages, NK cells, and cytotoxic T-cells via Dectin-1 receptor
• Ganoderic acids (triterpenoids): inhibit cholesterol synthesis needed by cancer cells, suppress COX-2
• Adaptogenic: clinically lowers cortisol and supports healthy stress response

Dual-extract (hot water + ethanol) is most potent — captures both beta-glucans and ganoderic acids. Dose: 1.5–9 g extract/day depending on product standardization. Traditional: 10–15 g dried Reishi simmered 1–2 hours in 1 liter water, 2 cups/day.

• Stabilizes liver cell membranes, prevents toxin entry
• Stimulates protein synthesis in liver cells — accelerates hepatocyte regeneration
• Powerful antioxidant in liver tissue — neutralizes free radicals from drug metabolites
• Helps liver process and eliminate chemo residues via glucuronidation

Especially important for: Survivors with elevated SGOT/SGPT, hepatitis B history, or history of hepatotoxic drugs (cisplatin, oxaliplatin, methotrexate).

Dose: 140–420 mg silybin/day (or 200–600 mg extract standardized to 70–80% silymarin). Take after meals as capsules.

• Clinical cortisol reduction: 27% decrease in 60 days (Chandrasekhar et al., 2012)
• Withaferin A: anti-angiogenic, inhibits Hsp90 (cancer cell protein chaperone), induces apoptosis
• Raises DHEA-S (anabolic hormone precursor) — often depleted in survivors from chronic cortisol

Dose: 300–600 mg standardized extract (2.5–5% withanolides), 1–2× daily with food. Traditional "Moon Milk": 1 tsp powder in warm almond milk + honey + cinnamon before bed.

• Potent immunomodulator: increases T-helper cells, NK cells, and macrophages
• Astragaloside IV activates telomerase (TERT) in immune cells — extends lifespan of immune cells shortened by chemo
• Adaptogen supporting adrenal function and cortisol regulation

Dose: 500–1,000 mg standardized extract 2–3× daily. Traditional: 15–30 g dried root simmered in soup 1–2 hours.

Evidence ★★★☆☆ | Priority: Moderate. Contains the most immunologically active beta-glucan known. Pilot study (Clinical Cancer Research, 2009) on breast cancer patients showed significant NK cell activity increase. Also has hypoglycemic effect — useful for insulin-resistant survivors.

Dose: 35 mg D-fraction extract 3× daily between meals (clinical trial dose) or 50–100 g fresh/dried mushroom in cooking daily. Use with caution during immunotherapy.

Evidence ★★☆☆☆ | Priority: Low-Moderate. Active compound thymoquinone (TQ) induces apoptosis, inhibits VEGF, and has hepatoprotective and immunomodulatory effects (mostly in vitro and animal studies; limited human trials).

Dose: ½–1 tsp cold-pressed oil 2× daily. Do not heat. Interacts with CYP2D6 and CYP1A2. Avoid >3 g/day oil — anticoagulant risk.

Evidence ★★☆☆☆ | Priority: Low-Moderate. Isothiocyanate moringine is structurally similar to sulforaphane from broccoli. Very high antioxidant ORAC score (6× blueberry). Blood sugar stabilizing effect. Nutrition is heat-sensitive — use fresh leaves or add powder at the end of cooking. Dose: 50–100 g fresh leaves/day or ½–1 tsp dried powder in smoothie.

Evidence ★★☆☆☆ | Priority: Moderate (without immunotherapy). Useful post-chemo for immune recovery after neutropenia, mild hepatoprotection, and anti-inflammatory support for mucosal recovery. Safe dose post-therapy (no immunotherapy): 200–400 mg standardized extract (10% andrographolide) 2× daily for 3 months, then 1 month off cycle. ⚠ Avoid if on any immunosuppressant or immunotherapy.